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Salicylic acid 0,5% - A21

Minor blemishes
  • Indications

    • Salicylic Acid 0,5% pure Active is recommended for small skin blemishes: skin blemishes and blackheads in particular.
      Etat Pur also offers Salicylic Acid 2% pure Active with a higher concentration of actives for very specific effects on spots and short-term intensive treatments.

  • Learn more

    • Salicylic Acid 0,5% has purifying, astringent and gentle exfoliant properties to even out the complexion. Little by little, impurities and dead cells are eliminated. It also regulates the pH of the surface of the skin to maintain good moisturization.

Quantity :
Size : 15 ml
(£46.7 / 100 ml)

SALICYLIC ACID 0,5% : Complementary products

Directions for use

For the entire face: apply 1 to 4 drops on the area of the face affected, avoiding the eye contour.


INITIAL TREATMENT : for more extensive blemishes (numerous blackheads, excess sebum and spots), we recommend using Salicylic acid 0,5% pure Active once or twice a day.
Depending on the nature of your skin and its sensitivity, we recommend that you alternate between Salicylic acid 0,5% pure Active and Salicylic acid 2% pure Active.

LONG-TERM TREATMENT : use once or twice a day. The specific effect of this active may cause slight tingling sensations when applied. This does not mean that treatment should be stopped.

INTENSIVE TREATMENT combining several pure Actives:
- For spots and acne-prone skin: use Salicylic acid 0,5% pure Active for 2 weeks and Zinc Gluconate pure Active morning and night. These two pure Actives are complementary and may be applied to the skin at the same time.
- For skin that presents blemishes and a dull complexion: use Salicylic acid 0,5% pure Active at night and Propolis pure Active in the morning.

After application, do not expose your skin to the sun. In the event of exposure, use suitable sun protection.

As an ideal complement, we recommend applying a Biomimetic skincare after the pure Active, suited to the nature and day-to-day needs of your skin.
Suggestion for the morning: Balancing matifying care.
Suggestion for the evening: Light moisturizing emulsion.

Efficacity proven

Scientific studies and recognized publications show that Salicylic Acid 70 mg acts at various levels in the skin:



Keratoregulatory effect (smoothing the complexion)
Salicylic Acid has a gentle and gradual exfoliant effect, which helps to smoothe the surface of the skin, while respecting its nature.



Regulatory effect
Salicylic Acid is also used to regulate the pH in the stratum corneum to:

  • enhance the skin's ability to maintain good moisturization
  • balance the cutaneous flora and sanitize the skin

References and proofs of effectiveness of Salicylic Acid (clinical studies, bibliographies and expert opinions)

PURE ACTIVE : Salicylic Acid, pure molecule (purity level = 100%) [SALICYLIC ACID]
The bottle contains 70 mg of pure Active
 This is the quantity needed so that each application done according to the directions for use provides the skin with the effective dose recommended by scientific studies.

Proven effectiveness

PATENTED IN-SKIN® SYSTEM : to treat the skin exactly where it is needed, Salicylic Acid 70 pure Active is combined with a unique delivery system.
It is totally absorbed by the skin so that it can interact with the cells in depth.
*eau isodermique / isodermic water.

Learn more

Scientific history

Salicylic Acid is a natural molecule which was first found in white willow and later in large quantities in meadowsweet, Spiraea ulmaria, which gave its name to Aspirin.

The medicinal properties of Salicylic Acid have been known for a long time, especially for their effect against fever and pain.

In Antiquity, Greek doctors would recommend infusions based on willow leaves to relieve pain.

To combat fever, its synthetic form (acetylsalicylic acid marketed under the name "Aspirin") is particularly effective to the extent that it has become the bestselling drug in the world (120 billion pills).

Salicylic Acid is universally used in dermatology for its keratolytic effect.

Origin / Video

A molecule naturally present in white willow and meadowsweet, Salicylic Acid is now widely manufactured by a process based on biosynthesis.

This is the method used to obtain it selected by ETAT PUR. The producer meets very strict quality standards specific to the pharmaceutical industry.
The active is concentrated and purified until 100% pure Salicylic Acid is obtained.

The video

The quality control of this ingredient is handled by DIPTA, the research centre and inspection laboratory for the ETAT PUR, BIODERMA and ESTHEDERM brands in Aix-en-Provence.

All details concerning the origin and quality of this pure Active are filed by ETAT PUR and can be accessed by all inspection bodies, which guarantees us total confidentiality in data processing.

Opinion of the dermatologist

Salicylic Acid 0,5% - Pure Active A21

Salicylic acid has been known and used in medicine for centuries. In dermatology, it is used for its exfoliating and keratolytic properties. This molecule is therefore interesting if you present with predominantly retentional acne, i.e. if you have few red spots but mainly small cysts or blackheads, making your skin look rough and uneven. By refining the outermost layers of the epidermis, this pure Active will foster the elimination of cysts and limit their formation.

If you also have red spots (mixed acne), you can combine Salicylic acid with Zinc Gluconate pure Active.

At this relatively weak concentration ([70]), the effectiveness will be less than with the stronger concentration ([300]) but with enhanced tolerance. So try it if you are intolerant to the stronger concentration or as the first step if you have sensitive skin.

Customer Reviews about : SALICYLIC ACID 0,5%

Tracey - 9/2/2016
  • 36-45 years
  • Oily
Long term help
I started out with A22 (for two years) and after much success thought it would be worth trying a lower concentration. I now use A22 in the morning and A21 in the evening which means I have reduced the concentration of acid on my face over the day. So far (3 months) with great success and no reduced efficacy.

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Logo In-Skin

As it is not enough for an active to be pure to act wherever the skin needs it, ETAT PUR has developed a specific formula that enhances the penetration of each pure Active.
Each formula is carefully designed to convey the pure Active dynamically to its target in the skin in order to optimise its effectiveness.
This is the patented IN-SKIN ® system.

One of the main functions of the skin is its barrier function.

It works in both directions:

  • It prevents the loss of water, electrolytes and other constituents in the human body
  • And prevents the penetration of molecules from the environment

This barrier function is not identical, however, over the entire surface of the skin (pilosebaceous canals, eye contour area, depending on the part of the body...) and it is this relative permeability that is involved in the absorption of actives through the skin.
The very nature of the majority of actives conditions their absorption by topical means.
To facilitate their absorption, it is essential to combine them with a "carrier" that will ensure that they are conveyed to the appropriate destination.
This is the primary function of the patented IN-SKIN system.