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Hyaluronic acid - A06

Deep wrinkles, loss of firmness
  • Indications

    • LW Hyaluronic Acid pure Active is especially recommended for deep wrinkles and loss of firmness. It is also indicated for skin regeneration: after an acne treatment, intense sun exposure or in serious cases of stress...

  • Learn more

    • Hyaluronic Acid is naturally present in the skin. It plays a fundamental role in maintaining its integrity. But its quantity gradually diminishes with age, leading to the appearance of wrinkles and a slackening of skin tissue. Only low molecular weight Hyaluronic Acid penetrates the deep layers of the skin to regenerate the dermal matrix. It stimulates the skin so that it can once again synthesize its own molecules. The skin is smooth and regains its suppleness and tonicity.

Quantity :
Size :
(£140.0 / 100 ml)

HYALURONIC ACID : Complementary products

Directions for use

 For the entire face: apply 4 drops to the entire face, concentrating in the wrinkles.

INITIAL TREATMENT : use morning and night for 1 month. This pure Active forms a film that naturally moisturises and protects the skin. We recommend using it on its own (no point in applying a moisturising cream afterwards).

LONG-TERM TREATMENT : use once a day, preferably at night. Can be used as long as necessary. This pure Active forms a film that naturally moisturises and protects the skin. We recommend using it on its own (no point in applying a moisturising cream afterwards).

INTENSIVE TREATMENT combining several pure Actives:
- For deep wrinkles: use Hyaluronic Acid pure Active for 1 month at night and Resveratrol pure Active in the morning. Repeat at least 3 times a year.
- For early wrinkles (excess sun exposure, smoking...): use Hyaluronic Acid pure Active for 1 month at night. Repeat at least 3 times a year.
- For mature, fine and fragile skin: use Hyaluronic Acid pure Active for 1 month at night and Mimosa tenuiflora pure Active in the morning. Repeat treatment if necessary.

If you want to apply a Biomimetic skincare product after Hyaluronic Acid pure Active, "lint" may form. This in no way impairs the effectiveness of the active. This pure Active forms a film that naturally moisturises and protects the skin. We recommend using it on its own (no point in applying a moisturising cream afterwards).

Efficacity proven

Scientific studies and recognized publications show that low molecular weight Hyaluronic Acid acts at various levels in the skin:



Regenerating effect on the dermal matrix
Several in-vitro studies reveal the ability of Hyaluronic Acid to stimulate collagen synthesis and increase the proliferation of fibroblasts. These cells naturally synthesize collagen fibres, elastin and Hyaluronic Acid in the skin.

Stimulated in this way, the skin is regenerated and its dermal matrix redensified. The skin is firmer and wrinkles concealed.



Stimulation of skin regeneration
In-vivo studies have shown that the application of Hyaluronic Acid significantly improves skin regeneration:

  • activation of re-epithelialization
  • regulation of cell proliferation and migration
  • attenuation of the roughness of the newly formed epidermis

The repaired tissue is of better quality and the scars less marked.



Optimization of the skin's ability to retain water
In-vitro studies have revealed the stimulating effect of Hyaluronic Acid on the synthesis of proteins involved in the skin's natural hydric flows. The skin's ability to retain water molecules is thus improved.

References and proofs of effectiveness of Hyaluronic Acid (clinical studies, bibliographies and expert opinions)

PURE ACTIVE : **Hyaluronic Acid, pure molecule (purity level > 85%) [HYDROLYZED HYALURONIC ACID]
The bottle contains 100 mg of pure Active.
This is the quantity needed so that each application done according to the directions for use provides the skin with the effective dose recommended by scientific studies.

Proven effectiveness

PATENTED IN-SKIN® SYSTEM : to treat the skin exactly where it is needed, LW Hyaluronic Acid pure Active is combined with a unique delivery system.
It is totally absorbed by the skin so that it can interact with the cells in depth.

*eau isodermique / isodermic water.
Scientific history

Hyaluronic Acid is a molecule found naturally in all vertebrates, mainly in the conjunctive, epithelial and nerve tissues. It is one of the main constituents of the extracellular matrix. This matrix allows cells to organize themselves in tissue. More than 50% of the total Hyaluronic Acid in the body is present in the skin! Which explains the importance of its contribution to the condition of our skin.

Hyaluronic Acid is a natural constituent in the dermis and plays an important role in the moisturization and elasticity of the skin. It is in young organisms that it is found in the largest quantity. Indeed, over time, its presence diminishes, because the free radicals to which we are exposed (sun, pollution...) destroy it. Little by little, our skin dries out and wrinkles.

It is estimated that, at 50 years of age, men and women have only half of the quantity of Hyaluronic Acid that they had in childhood.

Capable of retaining more than 1,000 times its weight in water, it restores the skin's elastic properties, helps to moisturize it and smoothe its surface.

Its structure was established in the 1930s in Karl Meyer's laboratory. Since then, this molecule has been studied constantly. There are various different qualities of Hyaluronic Acid, the principal difference being in their molecular weight. They are used in dermatology, plastic surgery and pharmacy.

In plastic surgery, high molecular weight Hyaluronic Acid is injected into the dermis to restore an immediate smooth and rounded appearance to the skin.

When it is applied to the surface of the skin to regenerate it, the size of the molecule must be sufficiently small to be able to penetrate the deepest layers.

This is why ETAT PUR has selected a low molecular weight Hyaluronic Acid (Low Weight - LW) to act effectively on the regeneration of the skin matrix.

Origin / Video

Hyaluronic Acid is naturally present in the skin. So as to obtain a low molecular weight Hyaluronic Acid of excellent quality, ETAT PUR has chosen a biotechnological process.

The method used is natural: it involves lactic bacteria and plant substrates (wheat and sugar beet) and plant alcohol to extract the active fraction sought.

Then come the concentration, hydrolysis and purification stages in order to obtain a low molecular weight Hyaluronic Acid more than 85% pure.

The video

The quality control of this ingredient is handled by DIPTA, the research centre and inspection laboratory for the ETAT PUR, BIODERMA and ESTHEDERM brands, in Aix-en-Provence.

All details concerning the origin and quality of this pure Active are filed by ETAT PUR and can be accessed by all inspection bodies, which guarantees us total confidentiality in data processing.

Opinion of the dermatologist

LW Hyaluronic Acid - Pure Active A06

By stimulating the proliferation of fibroblasts (dermal cells) and the production of collagen and hyaluronic acid, this molecule helps to redensify the skin and reduce wrinkles. Its favourable effect on skin moisturization is also beneficial. Tolerance is optimal as it is a molecule found naturally in the dermis.

Its use in cosmetics is limited by the difficulties this large molecule has penetrating the epidermis. This is why we use low molecular weight molecules. High molecular weight hyaluronic acids are used in cosmetic dermatology as wrinkle-filling products where they are injected directly into the dermis to lift the wrinkle.

Customer Reviews about : HYALURONIC ACID

Anne - 3/23/2014
  • 26-35 years
  • Combination
Excellent product
Using this product in connection with a simple moisturiser guarantees better results than many of the more expensive creams and serums on the market.
I'm delighted with this product!
Tamara - 11/7/2013
  • 56-65 years
  • Dry
I am very happy with this product!
I can say in my age that I am expert with anti-aging cosmetic but I've been surprise, when I got this product.I want recommended use Etat Pur! It's worked and achievable.

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Logo In-Skin

As it is not enough for an active to be pure to act wherever the skin needs it, ETAT PUR has developed a specific formula that enhances the penetration of each pure Active.
Each formula is carefully designed to convey the pure Active dynamically to its target in the skin in order to optimise its effectiveness.
This is the patented IN-SKIN ® system.

One of the main functions of the skin is its barrier function.

It works in both directions:

  • It prevents the loss of water, electrolytes and other constituents in the human body
  • And prevents the penetration of molecules from the environment

This barrier function is not identical, however, over the entire surface of the skin (pilosebaceous canals, eye contour area, depending on the part of the body...) and it is this relative permeability that is involved in the absorption of actives through the skin.
The very nature of the majority of actives conditions their absorption by topical means.
To facilitate their absorption, it is essential to combine them with a "carrier" that will ensure that they are conveyed to the appropriate destination.
This is the primary function of the patented IN-SKIN system.