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Zinc gluconate - A20

Shine, excess sebum
  • Indications

    • Zinc Gluconate pure Active is recommended for its effect on skin blemishes (shine, spots, blackheads...). Their presence is often the result of significant sebum secretion and a disturbance of the microbial flora in the skin.

  • Learn more

    • Zinc is a trace element used widely in dermatology for its sebo-regulatory, antibacterial, cicatrizing, antioxidant and anti-inflammatory properties. Very comprehensive, it rebalances sebum secretion and purifies the skin. Zinc also stimulates skin tissue repair and limits the appearance of redness.

ZINC GLUCONATE : Complementary products

Directions for use

For the entire face: apply 4 drops to the cleansed skin. Massage until completely absorbed.
For application to an isolated spot: apply one drop and massage to work in.

INITIAL TREATMENT : use morning and night. Minimum period of use: 1 week.
If necessary, use every day over a longer period, until you see a visible improvement in skin condition.

INTENSIVE TREATMENT combining several pure Actives:
- If the skin is also subject to blackheads: use Zinc Gluconate pure Active for 2 weeks morning and night and Salicylic acid 0,5% pure Active at night.
- For acne-prone skin (numerous spots, redness and shiny areas): use Zinc Gluconate pure Active for 1 month morning and night and Salicylic acid 2% pure Active at night. Repeat if necessary or use twice a week as a precaution against recurrence.
- If the complexion is dull: use Zinc Gluconate pure Active every day for 1 week morning and night and Propolis pure Active in the morning. Use twice a week as a precaution.

As an ideal complement, we recommend applying a Biomimetic skincare after the pure Active, suited to the nature and day-to-day needs of your skin.
Suggestion for combination or oily skin:
- Night cream: Light moisturizing cream.
Suggestion for dull complexions
- Day cream: Radiant complexion care.

Efficacity proven

Scientific studies and recognized publications show that Zinc acts at various levels in the skin:



Sebo-regulatory effect
Overproduction of sebum is often the main cause of skin blemishes. Zinc inhibits the activity of the key enzyme in sebum secretion: 5-α-reductase. It therefore rebalances and regulates sebum production while limiting the appearance of spots on the surface of the skin.



Purifying and reparative power
Thanks to its antibacterial activity, Zinc purifies and effectively sanitizes the skin. It rids it of the microorganisms involved in spot formation. Furthermore, by stimulating the proliferation of epidermal cells, Zinc promotes and accelerates skin regeneration.



Protective and soothing effect
Zinc soothes fragile skin by easing skin redness. This trace element is also an anti-free radical capable of providing the skin with long-lasting protection. Skin firmness and elasticity are therefore preserved.

References and proofs of effectiveness of Zinc (clinical studies, bibliographies and expert opinions)

PURE ACTIVE : Zinc Gluconate, pure molecule (purity level > 97%) [ZINC GLUCONATE]
The bottle contains 435 mg of pure Active.
 This is the quantity needed so that each application done according to the directions for use provides the skin with the effective dose recommended by scientific studies.

Proven effectiveness

PATENTED IN-SKIN® SYSTEM : to treat the skin exactly where it is needed, Zinc Gluconate pure Active is combined with a unique delivery system.
It is totally absorbed by the skin so that it can interact with the cells in depth.

Ingredients of the IN-SKIN® system

*eau isodermique / isodermic water.

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Scientific history

Zinc is a trace element naturally present in the human body, in trace amounts. It comes into play in approximately 200 enzymatic reactions. In the skin, Zinc occupies an important place. It is needed for cell division, growth and tissue regeneration. It is also involved in inhibiting the activity of 5-α-reductase, an enzyme involved in sebum secretion.

It is introduced into the organism mainly by diet.

The use of Zinc in medicine dates back to Antiquity. In ancient Egypt, preparations based on Zinc were already in use to improve wound cicatrization.

Over time, Zinc, in various forms (gluconate, sulphate, oxide...), has come to be an essential active principle in medicine and dermatology for treating mouth inflammations such as mouth ulcers, soothing nappy rash and alleviating the clinical signs of acne.

In dermatology, Zinc Gluconate is often preferred to Zinc as it is more stable and penetrates the skin better.

The antimicrobial properties of Zinc Gluconate have led to its frequent and practically unavoidable use in treating the various forms of acne.

Origin / Video

The quality of the Zinc   Gluconate selected by ETAT PUR is obtained by biosynthesis from Zinc of mineral origin and Gluconate derived from sugars and lactic acid. The Gluconates are obtained by a biotechnological process using sugars. Once produced, the Active is concentrated and purified until 97% pure Zinc Gluconate is obtained.

The production of Zinc Gluconate, made in the Netherlands, meets very strict quality standards. The Active is concentrated and purified until 97% pure Zinc Gluconate is obtained.

The video

The quality control of this ingredient is handled by DIPTA, the research centre and inspection laboratory for the ETAT PUR, BIODERMA and ESTHEDERM brands in Aix-en-Provence.

All details concerning the origin and quality of this pure Active are filed by ETAT PUR and can be accessed by all inspection bodies, which guarantees us total confidentiality in data processing.

Opinion of the dermatologist

Zinc Gluconate [435] mg - Pure Active A20

Zinc is a trace element widely used in dermatology for treating acne, whether orally or locally. It is especially recommended if you have moderate inflammatory acne (red spots containing pus). Its sebo-regulatory action also makes it interesting if you present with hyperseborrhea, i.e. an oily, shiny skin, particularly in the central areas of the face (forehead, nose, chin).

If you present with mixed acne (red spots as well as cysts and blackheads), you can combine it with Salicylic Acid pure Active.

If your acne is widespread and leaves scarring, consult your dermatologist straight away. He will be able to offer you a stronger treatment.

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