For the entire face: apply 1 to 4 drops to the area affected (1 drop for 1 isolated spot / 4 drops for the entire face).
This pure Active is also suitable for blemishes on the upper back, for example: apply 4 to 6 drops depending on the surface area to be treated.
INITIAL TREATMENT (for isolated spots) : use twice a day for at least 1 week. Continue treatment longer according to the extent of the blemishes. The molecule's activity may cause slight tingling sensations on application. This does not mean that treatment should be stopped.
LONG-TERM TREATMENT (for acne-prone skin) : use morning and night for one week, then once a day at night for 3 months. The molecule's activity may cause slight tingling sensations on application. This does not mean that treatment should be stopped. For sensitive and readily reactive skin, we recommend using Salicylic acid 0,5% pure Active, with a weaker concentration.
INTENSIVE TREATMENT combining several pure Actives:
- For spots and acne-prone skin: use Salicylic acid 2% pure Active and Zinc Gluconate pure Active morning and night. These two pure Actives are complementary and can be applied to the skin at the same time.
- For skin that presents blemishes and a dull complexion: use Salicylic acid 2% pure Active at night and Propolis pure Active in the morning.
After application, do not expose your skin to the sun. In the event of exposure, use suitable sun protection.
As an ideal complement, we recommend applying a Biomimetic skincare after the pure Active, suited to the nature and day-to-day needs of your skin.
Suggestion for the morning: Balancing matifying care.
Suggestion for the evening: Light moisturizing emulsion.
Scientific studies and recognized publications show that Salicylic Acid 300 mg acts at various levels in the skin:
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Keratolytic effect |
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Purifying effect |
The bottle contains 300 mg of pure Active.
Proven effectiveness

It is totally absorbed by the skin so that it can interact with the cells in depth.
*eau isodermique / isodermic water.
Salicylic Acid is a natural molecule which was first found in white willow and later in large quantities in meadowsweet, Spiraea ulmaria, which gave its name to Aspirin.
The medicinal properties of Salicylic Acid have been known for a long time, especially for their effect against fever and pain.
In Antiquity, Greek doctors would recommend infusions based on willow leaves to relieve pain.
To combat fever, its synthetic form (acetylsalicylic acid marketed under the name "Aspirin") is particularly effective to the extent that it has become the bestselling drug in the world (120 billion pills).
Salicylic Acid is universally used in dermatology for its keratolytic effect.
A molecule naturally present in white willow and meadowsweet, Salicylic Acid is now widely manufactured by a process based on biosynthesis.
This is the method used to obtain it selected by ETAT PUR. The producer meets very strict quality standards specific to the pharmaceutical industry.
The active is concentrated and purified until 100% pure Salicylic Acid is obtained.
The quality control of this ingredient is handled by DIPTA, the research centre and inspection laboratory for the ETAT PUR, BIODERMA and ESTHEDERM brands in Aix-en-Provence.
All details concerning the origin and quality of this pure Active are filed by ETAT PUR and can be accessed by all inspection bodies, which guarantees us total confidentiality in data processing.
Opinion of the dermatologist
Salicylic Acid 2% - Pure Active A22
Salicylic acid has been known and used in medicine for centuries. In dermatology, it is used for its exfoliating and keratolytic properties. This molecule is therefore interesting if you present with predominantly retentional acne, i.e. if you have few red spots but mainly small cysts or blackheads, making your skin look rough and uneven. By refining the outermost layers of the epidermis, this pure Active will foster the elimination of cysts and limit their formation.
If you also have red spots (mixed acne), you can combine Salicylic acid with Zinc Gluconate pure Active.
This relatively strong concentration ([300]) helps to optimize the molecule's effectiveness but may cause a degree of irritation. So begin with this concentration if you do not have particularly sensitive skin.