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Peptide-4 Pro-collagen - A12

Deep expression wrinkles
  • Indications

    • Peptide-4 Pro-collagen pure Active is recommended to treat established expression wrinkles on the eye contour, forehead or mouth. It is ideal for people aged 45+. It is also recommended as follow-up treatment after dermo-aesthetic care to optimise skin regeneration. 

  • Learn more

    • An expert active in the reconstruction of the dermal matrix, Peptide-4 helps skin recreate its own collagen, a protein that is essential in providing skin's density and firmness. Its biological action stimulates regeneration and improves resistance, consistency and elasticity of skin. Progressively skin's supporting tissue is restructured. Skin architecture is redefined and wrinkles are attenuated.

PEPTIDE-4 PRO-COLLAGEN : Complementary products

Directions for use

    Apply 4 drops to the whole face, concentrating on wrinkles and massaging until completely absorbed.

    To deliver the product, press on the bottom of the bottle with the forefinger.

LONG-TERM TREATMENT : use twice a day, morning and night, for at least 2 months.

 INTENSIVE TREATMENT  combining several pure Actives :

> For deeper wrinkles and loss of firmness : use Peptide-4 Pro-collagen pure Active in the morning and Hyaluronic Acid pure Active in morning and evening for two weeks.

> For skin weakened by dermo-aesthetic care : use Peptide-4 Pro-collagen pure Active, in morning and evening for two weeks. 

> For mature and fine skin, showing many fine lines : use Peptide-4 Pro-collagen pure Active in the morning and   Mimosa tenuiflora pure Active in the evening for one month.

This active is sensitive to high temperatures. To ensure that it continues to be effective, do not expose to a heat source. 

As an ideal complement, we recommend applying a Biomimetic skincare after the pure Active, suited to the nature and day-to-day needs of your skin.
Suggestion for the morning : Firming lifting care
Suggestion for the evening : Redensifying regenerating care
Suggestion for the eye contour : Smoothing eye contour care

Efficacity proven

Scientific studies and recognized publications show that Peptide-4 acts at various levels in the skin :

Peptide-4 Pro-collagen is a complex containing an active sequence of 3 amino acids called "GHK" (reference to the 3 amino acids composing it: Glycin (G) – Histidin (H) – Lysin (K)). This sequence is recognised for its efficacy on skin's supporting tissue.



Specific action on wrinkles

A clinical study has highlighted Peptide-4's ability to significantly reduce fine lines and wrinkles. Applied twice a day on healthy skin for 56 days, Peptide-4 reduces fine lines and wrinkles by an average 27%.



Redensifying action on the dermal matrix

Peptide-4 helps skin recreate its own collagen, a protein essential for dermal density and structure. It also stimulates biosynthesis of certain molecules of the skin's fundamental substance (proteoglycans, glycoaminoglycans).

These molecules are key components of the extracellular matrix and are intimately linked to skin's three-dimensional architecture.

In vivo, applied twice per day on healthy skin for 56 days, Peptide-4 increases dermal density for 78% of volunteers and homogeneity of the dermis for 70% of volunteers.



Tissue regeneration

In vitro studies have highlighted the capacity of the GHK sequence contained in Peptide-4 to stimulate the formation of new tissues by stimulation of VEGF (vascular endothelial growth factor). It also activates proliferation of fibroblasts (dermal cells producing skin's supporting fibres).

References and proofs of effectiveness of Peptide-4 (clinical studies, bibliographies and expert opinions)

PURE ACTIVEPeptide-4, pure molecule (purity level = 80%)  [CAPROOYL TETRAPEPTIDE-3].
The bottle contains 75 µg of pure Active.
This is the quantity needed so that each application done according to the directions for use provides the skin with the effective dose recommended by scientific studies.

Proven effectiveness

PATENTED IN-SKIN® SYSTEM : to treat the skin exactly where it is needed, Peptide-4 Pro-collagen pure Active is combined with a unique delivery system.
It is totally absorbed by the skin so that it can interact with the cells in depth.

*eau isodermique / isodermic water.

Scientific history

Peptides are essential components of all living proteins (collagen, elastin, muscle fibres, enzymes, etc.). A peptide is a chain of 2 to 10 amino acids.

Peptide-4 Pro-collagen is a complex containing an active sequence of three amino acids: glycin (G), histidin (H) and lysin (K). Also called tripeptide GHK, this sequence was discovered in 1973 by Dr. Loren Pickart. This peptide was then considerably studied for its regenerating and healing properties.

It has namely been demonstrated that this peptide is involved in several biological processes such as: repair of tissues, stimulation of collagen biosynthesis, stimulation of new blood vessels...

It was therefore natural for the pharmaceuticals industry to take a close interest in this very powerful molecule towards the late 1990s.

Nowadays, several pharmaceutical preparations designed to heal skin contain tripeptide GHK.

In the cosmetics industry, it is often grafted onto a chain of fatty acids to facilitate penetration into the skin. It is used to treat wrinkles or, more generally, to regenerate the dermal matrix, essential for maintaining skin.

Origin / Video

Peptide-4 selected by ETAT PUR is obtained by Biosynthesis. It is a Caprooyl tetrapeptide-3, a chain of 4 amino acids grafted to a fatty acid to facilitate its penetration into the innermost layers of the skin.

The producer satisfies very strict quality standards and guarantees a high degree of purity.

Peptide-4 is over 80% pure.

The quality control of this ingredient is handled by DIPTA, the research centre and inspection laboratory for the ETAT PUR, BIODERMA and ESTHEDERM brands, in Aix-en-Provence.

All details concerning the origin and quality of this pure Active are filed by ETAT PUR and can be accessed by all inspection bodies, which guarantees us total confidentiality in data processing.

Opinion of the dermatologist

Dans ce tetrapeptide de synthèse, la partie active est le tripeptide GHK (association de 3 acides aminés Glycine, Histidine, Lysine). Il est scientifiquement prouvé que ce tripeptide aide à la reconstruction cutanée en stimulant entre autre la production des constituants de la matrice extracellulaire.

Ainsi le tripeptide GHK redensifie la peau en stimulant la biosynthèse du collagène, de protéoglycanes et de glycoaminoglycanes contenus naturellement dans le derme. C’est la bonne qualité du derme, qui donne à la peau sa fermeté et sa densité.

Dans une étude clinique, il a été montré que le tripeptide GHK diminuait significativement la profondeur des rides et des ridules. Il s’agit donc d’une molécule anti-âge intéressante qui doit être utilisée sur une durée prolongée (plusieurs mois) puisque l’effet attendu de redensification dermique n’est bien sûr pas immédiat.


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