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Apigenin - A08

Dark circles
  • Indications

    • Apigenin pure Active is especially recommended for dark circles under the eyes.
      The eye contour area is the most fragile part of the face. The skin in this area is 5 times thinner. Dark circles appear in cases of fatigue and become more marked as time passes. They are principally related to a skin pigmentation disorder and fragile capillaries.

  • Learn more

    • Apigenin is a flavonoid known for its targeted effect on microcirculation and its ability to protect the skin matrix. Apigenin activates the elimination of the pigment responsible for the bluish colouring of the eye contour and reduces signs of fatigue.

APIGENIN : Complementary products

Directions for use

For each eye contour: apply 1 drop to the skin, under the eye. Massage gently from the outer corner of the eye to the inner corner.

INITIAL TREATMENT : use morning and night. Minimum period of use : 2 weeks.
If necessary, use every day over a long period, until you see a visible improvement of the eye contour.

LONG-TERM TREATMENT : use at least once a day, for at least 1 month.

INTENSIVE TREATMENT combining several pure Actives:
- If the eye contour also presents undereye puffiness: use Apigenin pure Active for 2 weeks in the morning and Ruscogenin pure Active at night. Repeat if need be, depending on the intensity of the dark circles and the undereye puffiness. The best results are obtained after 1 month's use every day.

External use only. Do not put in the eyes.

As an ideal complement, we recommend applying a Biomimetic skincare after the pure Active, suited to the nature and day-to-day needs of your skin.
Smoothing eye contour care.

Efficacity proven

Scientific studies and recognized publications show that Apigenin acts at various levels in the skin:



Effect on the colour of dark circles
Apigenin strengthens the dermal matrix and actively combats blood vessel fragility. Furthermore, Apigenin stimulates the elimination of bilirubin, the pigment responsible for the colour of dark circles.



Soothing property
Eye contour skin is very fine and often sensitive. Thanks to its anti-inflammatory properties, Apigenin soothes this frequently reactive area.



Protection of the skin
Apigenin provides the skin with long-lasting protection with its anti-free radical properties. It effectively inhibits metalloproteinase-1, the enzyme responsible for the degradation of collagen in the skin. Apigenin thus limits premature ageing of the eye contour.



Study conducted by an independent laboratory
A study conducted on 54 people who used Apigenin pure Active for 1 month in the morning and Ruscogenin pure Active at night has demonstrated its visible effectiveness:

  • Face less tired: 64%
  • Dark circles less coloured: 60%
  • Lightening of their dark circles: 60%
  • Reduction of the volume of undereye puffiness: 70%
  • Undereye puffiness less visible: 68%

References and proofs of effectiveness of Apigenin (clinical studies, bibliographies and expert opinions)

PURE ACTIVE : **Apigenin, pure molecule extracted from Grapefruit (purity level > 95%) [APIGENIN]
The bottle contains 25 mg of pure Active.
This is the quantity needed so that each application done according to the directions for use provides the skin with the effective dose recommended by scientific studies.

Proven effectiveness

PATENTED IN-SKIN® SYSTEM : to treat the skin exactly where it is needed, Apigenin pure Active is combined with a unique delivery system.
It is totally absorbed by the skin so that it can interact with the cells in depth.

*eau isodermique / isodermic water.
Scientific history

This natural molecule is present in numerous fruits and vegetables, including grapefruit.

Apigenin is a flavonoid with anti-free radical and protective powers.

The extraordinary virtues of grapefruit attracted the interest of scientists in the 20th century, particularly because it contains flavonoids, essential protective anti-free radical molecules. Since their discovery in the 1930s, (Szent-Györgyi, Nobel Prize 1937) flavonoids have continued to excite and revolutionize the scientific world owing to their diversity and effectiveness.

Among the flavonoids found in grapefruit, Apigenin is the one that has been most widely studied. In addition to its anti-free radical effect, recent scientific studies (2002, 2004 and 2007) have revealed its ability to eliminate bilirubin. This pigment is partly responsible for the characteristic colour of dark circles.

Origin / Video

This pure Active is extracted from grapefruit (Citrus paradisi).

The Grapefruit selected by ETAT PUR is grown in Spain, a country where weather conditions are ideal for its cultivation and ripening of the fruit.

The Apigenin is isolated from the grapefruit by hydroalcoholic extraction. Then follows a concentration phase and several drying phases in order to totally eliminate the water and alcohol. The active fraction sought is then concentrated and purified in order to obtain Apigenin which is more than 95% pure.

The video

The quality control of this ingredient is handled by DIPTA, the research centre and inspection laboratory for the ETAT PUR, BIODERMA and ESTHEDERM brands, in Aix-en-Provence.

All details concerning the origin and quality of this pure Active are filed by ETAT PUR and can be accessed by all inspection bodies, which guarantees us total confidentiality in data processing.

Opinion of the dermatologist

Apigenin - Pure Active A08

Dark circles under the eyes are related to the visibility of the haemoglobin (bluish-purple in colour) contained in the red blood corpuscles and its degradation products, bilirubin (yellow-brown in colour) and iron (grey in colour). As the skin in the eyelids is very fine, these pigments are visible owing to the transparency of this area. Dealing with these dark circles is difficult but cosmetic treatments are worth trying as they may give good results in some patients.

Apigenin improves the vascular walls and enhances the ability to eliminate bilirubin, which makes it a good active for treating dark circles.

Other treatments can be tried, such as laser treatment, which give uneven results depending on the patient. Make-up may also provide valuable help with the availability on the market of orange sticks for concealing purplish dark circles.

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