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Enoxolone - A43

Reactive skin, redness
  • Indications

    • Enoxolone pure Active is especially indicated for very reactive and irritated skin, that may present redness, burning sensations and discomfort: tingling sensations, tightness... Environmental damage (aggressive soap, inappropriate detergent, depilation, dermo-cosmetic treatment, cold, salt, wind...) is often the cause.

  • Learn more

    • Enoxolone has powerful soothing properties and acts specifically on the various mechanisms that control skin hypersensitivity to provide the skin with effective and long-lasting relief.

ENOXOLONE : Complementary products

Directions for use

For the entire face: apply 4 drops to clean, dry skin.

INITIAL TREATMENT : use morning and night for 1 week.

INTENSIVE TREATMENT combining several pure Actives:
- If the skin is fine and fragile: use Enoxolone pure Active for 1 week in the morning and Mimosa tenuiflora pure Active at night. Then continue using Mimosa tenuiflora pure Active for 3 weeks morning and night.
- If the skin is also rough and flaky: use Enoxolone pure Active for 1 week and D-Panthenol pure Active one after the other, morning and night.
- If the skin is dehydrated and tight: use Enoxolone pure Active for 1 week and Aloe vera pure Active one after the other, morning and night.

As an ideal complement, we recommend applying a Biomimetic skincare after the pure Active, suited to the nature and day-to-day needs of your skin.
Suggestion: Soothing lipid-replenishing care.

Efficacity proven

Scientific studies and recognized publications show that Enoxolone, also called glycyrrhetinic acid, acts at various levels in the skin:


Soothing effect on fragile skin
As a response to stress, the skin will react locally by allowing signs of irritation to appear: erythemas, diffuse redness, flushing, tingling sensations, tightness... These skin reactions are initiated by the synthesis and release of molecules called "inflammatory mediators".

By inhibiting the enzymes responsible for the production of these mediators, Enoxolone reduces irritant reactions and calms and soothes the skin.


Similar effect to corticoids
Enoxolone has "corticoid-mimetic" properties, which are also a source of its soothing effect.

In vivo, its effectiveness has been demonstrated on patients suffering from atopic dermatitis: significant reduction of erythema, oedema and itching.


Protective effect against redness caused by UV rays
The UVB rays generated by the sun cause the organism to unleash a cascade of defensive reactions that lead to the release of histamine. This molecule leads to an increase in the size of the blood vessels, excessive dilatation and a rush of blood, responsible for the red colour in the skin and burning sensations.

Enoxolone, by reducing the synthesis of histamine, rapidly soothes the skin and enables it to alleviate its irritant potential.

References and proofs of effectiveness of Enoxolone (clinical studies, bibliographies and expert opinions)

PURE ACTIVE : **Enoxolone, pure molecule extracted fromLiquorice roots (purity level > 98%) [GLYCYRRHETINIC ACID]
The bottle contains 280 mg of pure Active.
Proven effectiveness
PATENTED IN-SKIN® SYSTEM : to treat the skin exactly where it is needed, Enoxolone pure Active is combined with a unique delivery system.
It is totally absorbed by the skin so that it can interact with the cells in depth.
*eau isodermique / isodermic water.
Scientific history

The soothing and tonifying properties of Liquorice, known for several hundred years, have been learnt from the basics of Chinese medicine and its treatises on herbalism. We also find proofs of its ancestral use in the papyrus scrolls of the Egyptians.

Liquorice extracts, rich in Enoxolone, are now commonly used in phytotherapy and medicine as an anti-inflammatory. Enoxolone is an active pharmaceutical agent found in several forms of medication.

Locally applied, Enoxolone is used principally in the symptomatic treatment of moderate and not superinfected inflammatory incidents such as atopic eczema, solar erythema, seborrhaeic dermatitis, pruritis vulvae or insect stings.

In dermatology, Enoxolone is known to soothe reactive skin and reduce redness and burning sensations.

Origin / Video

Enoxolone is a natural molecule found in large quantities in the roots of Liquorice, Glycyrrhiza glabra (L.).

The Liquorice selected by ETAT PUR comes from China. Several environmentally friendly producers guarantee a constant supply of the fresh plant.

The active fraction sought is gradually extracted from the liquorice roots, concentrated and purified until Enoxolone more than 98% pure is obtained.

The video

The quality control of this ingredient is handled by DIPTA, the research centre and inspection laboratory for the ETAT PUR, BIODERMA and ESTHEDERM brands in Aix-en-Provence.

All details concerning the origin and quality of this pure Active are filed by ETAT PUR and can be accessed by all inspection bodies, which guarantees us total confidentiality in data processing.

Opinion of the dermatologist

Enoxolone - Pure Active A43

Enoxolone or glycyrrhetinic acid has anti-inflammatory properties equivalent to a low-activity local corticoid like hydrocortisone.

This concentration [280] is indicated for treating the majority of acute inflammatory manifestations on the face such as: sunburn, erythema (redness) after a dermatological procedure (laser, peeling, etc.), post-depilation erythema or shaving, insect bites, for example.

If the skin on your face is sensitive and chronically reactive, choose Bisabolol pure Active or Oat pure Active, which you can use for in depth treatment over a long period.

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